{"id":14072,"date":"2025-02-18T14:16:47","date_gmt":"2025-02-18T13:16:47","guid":{"rendered":"https:\/\/www.sciencepharma.com\/blog\/nanoparticles\/"},"modified":"2025-03-13T22:31:38","modified_gmt":"2025-03-13T21:31:38","slug":"nanoparticles-nanotechnology-medicine","status":"publish","type":"blog","link":"https:\/\/www.sciencepharma.com\/pl\/blog\/nanoparticles-nanotechnology-medicine\/","title":{"rendered":"Exploring the potential of Nanoparticles and Nanotechnology systems in medicinal products development and registration"},"content":{"rendered":"<p style=\"text-align: justify;\"><span data-preserver-spaces=\"true\">Have any of you used them? Had a contact with them? <\/span><span data-preserver-spaces=\"true\"><strong>Nanoparticles<\/strong> are everywhere around us. Undetectable by the human eye, nanoparticles can exhibit significantly different physical and chemical properties to their larger counterparts. Researchers realized the importance of nanoparticles when they found that size can significantly influence the physiochemical properties of such substances.\u00a0<br \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span data-preserver-spaces=\"true\">Although, currently, there is a coexistence of different definitions of nanomaterials in the EU <\/span>which<span data-preserver-spaces=\"true\"> causes discrepancies between some sectors, according to the European Commission recommendation issued in 2022, <strong>nanomaterials are natural, incidental, or manufactured material <\/strong>consisting of solid particles present, either on their own or as identifiable constituent particles in aggregates or agglomerates where 50% or more of these particles in the number-based size distribution fulfils at least one of the following conditions:<\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li><span data-preserver-spaces=\"true\">one<\/span><span data-preserver-spaces=\"true\"> or more external dimensions of the particle are in the <strong>size range 1 nm to 100 nm<\/strong>,\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/li>\n<li><span data-preserver-spaces=\"true\">the particle<\/span><span data-preserver-spaces=\"true\"> has an <strong>elongated<\/strong> shape, such as a rod, fibre, or tube, where <strong>two external dimensions are smaller than 1 nm<\/strong>, and the other dimension is <\/span><span data-preserver-spaces=\"true\">larger<\/span><span data-preserver-spaces=\"true\"> than 100 nm,<\/span><\/li>\n<li><span data-preserver-spaces=\"true\">the particle<\/span><span data-preserver-spaces=\"true\"> has a <strong>plate-like shape<\/strong>, with one external dimension <strong>smaller than 1 nm<\/strong> and the other dimensions <\/span><span data-preserver-spaces=\"true\">larger<\/span><span data-preserver-spaces=\"true\"> than 100 nm.<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span data-preserver-spaces=\"true\">To imagine <strong>nanosize<\/strong>, remember that the diameter of a <strong>human hair<\/strong> is 100 \u00b5m,<\/span><span data-preserver-spaces=\"true\"> and a <\/span><span data-preserver-spaces=\"true\"><strong>human cell<\/strong> is 10 \u00b5m. <strong>Bacteria<\/strong> are ~1 \u00b5m in size, while <strong>water molecule<\/strong> is ~0.1<\/span><span data-preserver-spaces=\"true\">nm<\/span><\/p>\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-gallery has-nested-images columns-default is-cropped wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"319\" data-id=\"13984\" src=\"https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2025\/01\/baner_www_szablon2-1024x319.png\" alt=\"Scale comparison of nanoparticles (1-100 nm) compared to glucose, antibody, human cells, bacteria, virus, cancer cell, a period, tenis ball and water drop, highlighting their size and unique properties.\" class=\"wp-image-13984\" srcset=\"https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2025\/01\/baner_www_szablon2-1024x319.png 1024w, https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2025\/01\/baner_www_szablon2-300x93.png 300w, https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2025\/01\/baner_www_szablon2-768x239.png 768w, https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2025\/01\/baner_www_szablon2-1536x478.png 1536w, https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2025\/01\/baner_www_szablon2-2048x637.png 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/figure>\n\n\n<p style=\"text-align: justify;\"><em>Fig. 1. The size of nanoparticles in relation to other objects<\/em><\/p>\n<p style=\"text-align: justify;\"><strong><span data-preserver-spaces=\"true\">Nanotechnology<\/span><\/strong><span data-preserver-spaces=\"true\"> is helping to improve, even revolutionize, many technology and industry sectors, including information technology, homeland security, cosmetics, transportation, energy, food safety, environmental science, and medicine. The <\/span><span data-preserver-spaces=\"true\">sector<\/span><span data-preserver-spaces=\"true\"> with the <\/span><span data-preserver-spaces=\"true\">greatest<\/span><span data-preserver-spaces=\"true\"> potential for expansion and development over the next decade is <\/span><strong><span data-preserver-spaces=\"true\">nanomedicine<\/span><\/strong><span data-preserver-spaces=\"true\">. <\/span><span data-preserver-spaces=\"true\">The words <\/span><strong><span data-preserver-spaces=\"true\">nanomedicine<\/span><\/strong><span data-preserver-spaces=\"true\">, <\/span><strong><span data-preserver-spaces=\"true\">nanotechnology<\/span><\/strong><span data-preserver-spaces=\"true\">, <\/span><strong><span data-preserver-spaces=\"true\">and nanodevices are used<\/span><\/strong><span data-preserver-spaces=\"true\"> in the public sphere, not just in the scientific one.<\/span><\/p>\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Nanoparticles presence around us<\/h2>\n\n\n<p style=\"text-align: justify;\">Let&#8217;s take a closer look at nanoparticles and their presence around us. Now, we can probably say that nanoparticles are everywhere, and we have daily contact with them. Do you believe 5 nm nanoparticles were found in the most popular worldwide beverages? Note that some nanoparticles occur naturally in some foods; a good example is milk. <strong>Casein micelles<\/strong> in milk are protein <strong>nano-spheres<\/strong>, which are more available for us to absorb. Ubiquitous additives in food are titanium dioxide, a whitening agent, or silicon dioxide, an anticaking agent; both usually contain microsize particles and nanoparticles. Nanoparticles can quickly and easily reach taste buds on the tongue, so their level of use could be decreased. Nanoparticles might also extend food shelf life or reduce the need for added fats.<\/p>\n<p style=\"text-align: justify;\">Nanomaterials not only impart critical advantages but can also cause toxicity because of their unwanted interactions with biological and cellular processes. The possible passage of nanomaterials into air, water, and soil ecosystems could result in diverse environmental impacts. Every day, in the public domain, we can read or hear about <strong>nanoplastic pollution<\/strong>, the detection of nanoplastics in wild organisms, and some aspects of the open debate on nanomaterial safety.<\/p>\n<p style=\"text-align: justify;\"><span data-preserver-spaces=\"true\">Many of us probably asked whether we have anything to fear. No, because the <\/span><strong><span data-preserver-spaces=\"true\">European Food Safety Authority<\/span><\/strong><span data-preserver-spaces=\"true\"> (<\/span><strong><span data-preserver-spaces=\"true\">EFSA<\/span><\/strong><span data-preserver-spaces=\"true\">) ensures food safety in Europe. Recently, EFSA published a new approach to risk assessment, including a discussion of challenges on assessing the safety of nanoparticles in food [1].\u00a0EFSA recommends a <\/span><strong><span data-preserver-spaces=\"true\">detailed physicochemical characterization of nanomaterials<\/span><\/strong><span data-preserver-spaces=\"true\">, covering <\/span><strong><span data-preserver-spaces=\"true\">toxicodynamics<\/span><\/strong><span data-preserver-spaces=\"true\"> and <\/span><strong><span data-preserver-spaces=\"true\">toxicokinetics<\/span><\/strong><span data-preserver-spaces=\"true\">. According to all EFSA regulations and recommendations, the focus during the assessment has to be on:<\/span><\/p>\n<ul>\n<li style=\"text-align: justify;\"><strong>degradation<\/strong>\/<strong>dissolution<\/strong>,<\/li>\n<li style=\"text-align: justify;\"><strong>genotoxicity<\/strong>,<\/li>\n<li style=\"text-align: justify;\"><strong>cytotoxicity<\/strong>,<\/li>\n<li style=\"text-align: justify;\"><strong>oxidative stress<\/strong>,<\/li>\n<li style=\"text-align: justify;\">and (pro-)<strong>inflammation characteristics<\/strong>.<\/li>\n<\/ul>\n<p style=\"text-align: justify;\">To summarize, there is no need to worry. EFSA monitors and regulates the requirements for food and feed products containing small particles, including nanoparticles.<\/p>\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Medical applications of nanoparticles &#8211; Nanotechnology Product Database and scientific guidelines<\/h2>\n\n\n<p style=\"text-align: justify;\"><span data-preserver-spaces=\"true\">Let&#8217;s move on<\/span> <span data-preserver-spaces=\"true\">to the medical applications of nanoparticles. The <\/span><strong><span data-preserver-spaces=\"true\">Nanotechnology Product Database<\/span><\/strong><span data-preserver-spaces=\"true\"> currently (March 2025) contains 1318 products from 578 companies and 48 countries. Interestingly, the database divides a product into six categories:<\/span><\/p>\n<ul>\n<li style=\"text-align: justify;\"><strong>dentistry<\/strong> (90 products),<\/li>\n<li style=\"text-align: justify;\"><strong>disinfection<\/strong> (103 products),<\/li>\n<li style=\"text-align: justify;\"><strong>medical supplies<\/strong> (506 products),<\/li>\n<li style=\"text-align: justify;\"><strong>pharmaceutics<\/strong> (432 products),<\/li>\n<li style=\"text-align: justify;\"><strong>prosthesis<\/strong> and <strong>orthopedy<\/strong> (26 products),<\/li>\n<li style=\"text-align: justify;\">and<strong> tissue engineering<\/strong> 61 (products) [2].<\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span data-preserver-spaces=\"true\">The <\/span><strong><span data-preserver-spaces=\"true\">European Medicines Agency<\/span><\/strong><span data-preserver-spaces=\"true\"> (EMA) published scientific<\/span><strong><span data-preserver-spaces=\"true\"> guidelines on nanomedicines<\/span><\/strong><span data-preserver-spaces=\"true\">, which help drug product developers prepare <\/span><strong><span data-preserver-spaces=\"true\">marketing authorisation applications<\/span><\/strong><span data-preserver-spaces=\"true\"> for <\/span><strong><span data-preserver-spaces=\"true\">nanohuman medicines<\/span><\/strong><span data-preserver-spaces=\"true\">. A complete list of EMA scientific guidelines regarding nanomedicines can be found <\/span><a class=\"editor-rtfLink\" href=\"https:\/\/www.ema.europa.eu\/en\/human-regulatory-overview\/research-and-development\/scientific-guidelines\/multidisciplinary-guidelines\/multidisciplinary-nanomedicines\" target=\"_blank\" rel=\"noopener\"><span data-preserver-spaces=\"true\">here.<\/span><\/a><\/p>\n<p style=\"text-align: justify;\"><span data-preserver-spaces=\"true\">Moreover, for <\/span><strong><span data-preserver-spaces=\"true\">Marketing Authorization Applications<\/span><\/strong><span data-preserver-spaces=\"true\"> (MAA) in Europe, the regulatory system allows regulators to provide \u201c<\/span><strong><span data-preserver-spaces=\"true\">scientific counselling<\/span><\/strong><span data-preserver-spaces=\"true\">\u201d to applicants from the early stages of research and development.<\/span><\/p>\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Advancements in nanotechnology for drug delivery <\/h3>\n\n\n<p style=\"text-align: justify;\">Every material&#8217;s properties change as its size approaches the atomic scale due to the increasing <strong>surface area to volume ratio<\/strong>. <span data-preserver-spaces=\"true\">Nanoparticles&#8217; very small size and high surface area to volume ratio, compared to non-nano-size materials, are the unique features causing nanoparticles&#8217; extraordinary <\/span><strong><span data-preserver-spaces=\"true\">optical, physical, and chemical properties<\/span><\/strong><span data-preserver-spaces=\"true\">. It\u2019s worth noting that nanoparticles are small enough to confine their electrons and produce quantum effects.<\/span><\/p>\n\n\n<figure class=\"wp-block-gallery has-nested-images columns-default is-cropped wp-block-gallery-2 is-layout-flex wp-block-gallery-is-layout-flex\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"319\" data-id=\"13967\" src=\"https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2025\/01\/baner_www_szablon1-1024x319.png\" alt=\"Diagram showing different classes of nanomaterials used in the medical domain, including metal nanoparticles, polymer nanocomposites, liposomes, biodegradable polymers, polymer nanocomposites, carbon nanomaterials, magnetic nanomaterials, hydrogel nancomposites, nano rods, nano wires, tubes, fibers, platelets, semiconductor nanomaterials for drug delivery, highlighting their unique properties and applications in enhancing bioavailability and overcoming solubility challenges.\" class=\"wp-image-13967\" srcset=\"https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2025\/01\/baner_www_szablon1-1024x319.png 1024w, https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2025\/01\/baner_www_szablon1-300x93.png 300w, https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2025\/01\/baner_www_szablon1-768x239.png 768w, https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2025\/01\/baner_www_szablon1-1536x478.png 1536w, https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2025\/01\/baner_www_szablon1-2048x637.png 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/figure>\n\n\n<p><em><span data-preserver-spaces=\"true\">Fig. 2. Various classes of nanotechnology-based materials for medical application [3]<\/span><\/em><\/p>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<h3>Nanoparticle production methodologies<\/h3>\n<p style=\"text-align: justify;\">Advanced <strong>single-step<\/strong> and <strong>multi-step nanoparticle<\/strong> production and <strong>isolation methodologies<\/strong> are being developed and used:<\/p>\n<ul>\n<li style=\"text-align: justify;\"><strong> RESS<\/strong> (Rapid Expansion of Supercritical Solutions),<\/li>\n<li style=\"text-align: justify;\"><strong>SAS<\/strong> (Supercritical antisolvent),<\/li>\n<li style=\"text-align: justify;\"><strong>SAS-WTS<\/strong> (Supercritical antisolvent process integrated with Wurster type coater),<\/li>\n<li style=\"text-align: justify;\"><strong>SAS-EM<\/strong> (Supercritical Antisolvent Precipitation with Enhanced Mass transfer),<\/li>\n<li style=\"text-align: justify;\"><strong>SpEDS<\/strong> (Suspension-Enhanced Dispersion by Supercritical Fluid),<\/li>\n<li style=\"text-align: justify;\"><strong>SAS-DEM<\/strong> (Supercritical antisolvent \u2013 Drug Excipient Mixing),<\/li>\n<li style=\"text-align: justify;\"><strong>RESS-WTS<\/strong> (Rapid Expansion of Supercritical Solutions process in combination with the Wurster coater),<\/li>\n<li style=\"text-align: justify;\"><strong>RESS-BFB<\/strong> (Rapid Expansion of Supercritical Solutions process in combination with the Fluidised Bed),<\/li>\n<li style=\"text-align: justify;\"><strong>SAS-FB<\/strong> (Supercritical Antisolvent Precipitation with Fluidised Bed).<\/li>\n<\/ul>\n\n\n<div style=\"height:19px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"788\" src=\"https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2025\/02\/nanoparticles-production-1024x788.jpg\" alt=\"Diagram illustrating single-step and multi-step nanoparticle production and isolation methods, highlighting techniques such as encapsulation, nanosuspension formation, and supercritical fluid processes for enhancing drug delivery systems and improving bioavailability of poorly soluble APIs.\" class=\"wp-image-14032\" style=\"width:520px;height:auto\" srcset=\"https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2025\/02\/nanoparticles-production-1024x788.jpg 1024w, https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2025\/02\/nanoparticles-production-300x231.jpg 300w, https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2025\/02\/nanoparticles-production-768x591.jpg 768w, https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2025\/02\/nanoparticles-production.jpg 1300w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n<p><em>Fig. 3. Single-step and multi-step nanoparticle production and isolation methodologies [7]<\/em><\/p>\n\n\n<div style=\"height:29px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<h3 style=\"text-align: justify;\">Nanoparticles advancing the development of poorly water-soluble API&#8217;s medicinal products<\/h3>\n<p style=\"text-align: justify;\"><span data-preserver-spaces=\"true\">Nanoparticles also play a crucial role in solving one of the pharmaceutical industry&#8217;s <\/span><span data-preserver-spaces=\"true\">huge<\/span><span data-preserver-spaces=\"true\"> challenges: the poor <\/span><strong><span data-preserver-spaces=\"true\">solubility<\/span><\/strong><span data-preserver-spaces=\"true\"> of many active substances in water. Nearly 40-50% of the valuable oral drugs marketed in the USA and Europe and almost 90% of the new chemical active substances in the drug development stage are <\/span><strong><span data-preserver-spaces=\"true\">poorly water-soluble<\/span><\/strong><span data-preserver-spaces=\"true\">. For poorly soluble APIs, <\/span><strong><span data-preserver-spaces=\"true\">nano-drug delivery systems<\/span><\/strong><span data-preserver-spaces=\"true\"> and techniques open a new era for generating nanoproducts, which includes, e.g.:<\/span><\/p>\n<ul>\n<li style=\"text-align: justify;\"><strong>canonization<\/strong>,<\/li>\n<li style=\"text-align: justify;\">complex or <strong>micelle<\/strong> formation,<\/li>\n<li style=\"text-align: justify;\"><strong>encapsulation, <\/strong><\/li>\n<li style=\"text-align: justify;\"><strong>nanosuspension<\/strong> formation,<\/li>\n<li style=\"text-align: justify;\"><strong>supercritical fluid<\/strong>,<\/li>\n<li style=\"text-align: justify;\"><strong>high gravity precipitation<\/strong>,<\/li>\n<li style=\"text-align: justify;\">no precipitation techniques,<\/li>\n<li><strong> nano gels<\/strong>, or <strong>nano matrices<\/strong> formation.<\/li>\n<\/ul>\n<p><span data-preserver-spaces=\"true\">Old, well-recognized techniques, like <\/span><strong><span data-preserver-spaces=\"true\">spray drying<\/span><\/strong><span data-preserver-spaces=\"true\"> and <\/span><strong><span data-preserver-spaces=\"true\">freeze drying<\/span><\/strong><span data-preserver-spaces=\"true\">, are also used in the new version.<\/span><\/p>\n<p style=\"text-align: justify;\"><span data-preserver-spaces=\"true\">Nano-based systems are also attractive for many other reasons, including their ability to <strong>protect APIs from degradation<\/strong>, both in storage and after the drug is administered to the patient, during the API\u2019s transport to the target site within the body.\u00a0<\/span>Moreover, nanoparticles <strong>can affect the drug interactions<\/strong> with the cells at the target site. Finally, nanoparticles can influence the distribution and time of product circulation before elimination.<\/p>\n<\/p>\n<h3>Scope of currently approved medicinal products containing nanoparticles<\/h3>\n<p style=\"text-align: justify;\">Over the last two decades, the <strong>Food and Drug Administration<\/strong> (FDA) and <strong>EMA<\/strong> have approved nearly <strong>80 nanoparticle products <\/strong>[4]. Currently, the majority of approved therapeutic nanoparticles are in the EU market. The available nano-drugs demonstrated that they:<\/p>\n<ul>\n<li><strong>enhance active substance bioavailability<\/strong>,<\/li>\n<li><strong>eliminate some side effects<\/strong>,<\/li>\n<li>and deeply <strong>increase the therapeutic effect overall<\/strong>.<\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span data-preserver-spaces=\"true\">The first nano-drug for cancer treatment was a PEGylated liposomal formulation of <\/span><strong><span data-preserver-spaces=\"true\">doxorubicin<\/span><\/strong><span data-preserver-spaces=\"true\">. Nowadays, many <\/span><strong><span data-preserver-spaces=\"true\">nanocrystal-based<\/span><\/strong><span data-preserver-spaces=\"true\"> and <\/span><strong><span data-preserver-spaces=\"true\">lipid-based nanoparticle products<\/span><\/strong><span data-preserver-spaces=\"true\"> are available on the market. One of the last top uses is lipid nanoparticles as a delivery system for nucleic acids, including <\/span><strong><span data-preserver-spaces=\"true\">mRNAs in the COVID-19 vaccine<\/span><\/strong><span data-preserver-spaces=\"true\"> [5,6].<\/span><\/p>\n<p style=\"text-align: justify;\">Many drugs are in the <strong>pipeline<\/strong>, such as products based on:<\/p>\n<ul>\n<li style=\"text-align: justify;\">soy phosphatidylcholine (SPC-3),<\/li>\n<li style=\"text-align: justify;\">cholesterol,<\/li>\n<li style=\"text-align: justify;\">dipalmitoyl phosphatidyl glycerol (DPPG),<\/li>\n<li style=\"text-align: justify;\">methoxy-PEG-stearoyl phosphatidyl ethanolamine (mPEG2000-DSPE),<\/li>\n<li style=\"text-align: justify;\">chitosan,<\/li>\n<li style=\"text-align: justify;\">number of modified polymers,<\/li>\n<li style=\"text-align: justify;\">silica-based nanoparticles,<\/li>\n<li style=\"text-align: justify;\">metallic nanoparticles,<\/li>\n<li style=\"text-align: justify;\">carbon nanotubes,<\/li>\n<li style=\"text-align: justify;\">dendrimers<\/li>\n<li style=\"text-align: justify;\">or nanodiamonds.<\/li>\n<\/ul>\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Nanoparticles in regenerative medicine<\/h3>\n\n\n<p><span data-preserver-spaces=\"true\">A challenging interest of nanoparticles in medicine is <\/span><strong><span data-preserver-spaces=\"true\">regenerative therapy<\/span><\/strong><span data-preserver-spaces=\"true\">, which mainly focuses on designing new <\/span><strong><span data-preserver-spaces=\"true\">biocompatible materials<\/span><\/strong><span data-preserver-spaces=\"true\"> to <\/span><strong><span data-preserver-spaces=\"true\">enhance tissue repair<\/span><\/strong><span data-preserver-spaces=\"true\"> and <\/span><strong><span data-preserver-spaces=\"true\">regeneration<\/span><\/strong><span data-preserver-spaces=\"true\">. As life expectancy increases, interest in developing and directly administering therapeutic nanoparticles to promote <\/span><strong><span data-preserver-spaces=\"true\">bone regeneration<\/span><\/strong><span data-preserver-spaces=\"true\"> increases. The most advanced nano-delivery systems for bone regeneration are:<\/span><\/p>\n<ul>\n<li><strong><span data-preserver-spaces=\"true\"> synthetic PLA or PLGA,<\/span><\/strong><\/li>\n<li><span data-preserver-spaces=\"true\">or <\/span><strong><span data-preserver-spaces=\"true\">natural polymers <\/span><\/strong><span data-preserver-spaces=\"true\">such as <\/span><strong><span data-preserver-spaces=\"true\">collagen, gelatin, albumin, and chitosan<\/span><\/strong><span data-preserver-spaces=\"true\">.<\/span><\/li>\n<\/ul>\n<p><span data-preserver-spaces=\"true\">Besides polymeric, various formulations of <\/span><strong><span data-preserver-spaces=\"true\">non-polymeric nanoparticles (silica-based, metallic)<\/span><\/strong><span data-preserver-spaces=\"true\"> have also been used as nano-delivery systems for bone regeneration. <\/span><strong><span data-preserver-spaces=\"true\">Calcium phosphate-based <\/span><\/strong><span data-preserver-spaces=\"true\">non-polymeric nanoparticles are mostly used due to their similarities to human bone.<\/span><\/p>\n<p><strong><span data-preserver-spaces=\"true\">Micro<\/span><\/strong><span data-preserver-spaces=\"true\">\/<\/span><strong><span data-preserver-spaces=\"true\">nanomotors<\/span><\/strong><span data-preserver-spaces=\"true\"> for regenerative medicine are developing rapidly. Main design strategies include:<\/span><\/p>\n<ul>\n<li><strong><span data-preserver-spaces=\"true\"> 3D-printing, <\/span><\/strong><\/li>\n<li><strong><span data-preserver-spaces=\"true\">microfluidic, <\/span><\/strong><\/li>\n<li><strong><span data-preserver-spaces=\"true\">biohybrid, <\/span><\/strong><\/li>\n<li><strong><span data-preserver-spaces=\"true\">and polymer template methods<\/span><\/strong><span data-preserver-spaces=\"true\"> [8].<\/span><\/li>\n<\/ul>\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p style=\"text-align: justify;\"><span data-preserver-spaces=\"true\">Soon, what is probably not easy to imagine for all of you is <\/span><strong><span data-preserver-spaces=\"true\">that nanorobots<\/span><\/strong><span data-preserver-spaces=\"true\"> can be one of the options for <\/span><strong><span data-preserver-spaces=\"true\">cancer treatments<\/span><\/strong><span data-preserver-spaces=\"true\">; many such vehicles have made a way from theory to practice, from <\/span><em><span data-preserver-spaces=\"true\">in vitro<\/span><\/em><span data-preserver-spaces=\"true\"> experiments to <\/span><em><span data-preserver-spaces=\"true\">in vivo<\/span><\/em><span data-preserver-spaces=\"true\"> applications [9]. A crucial aspect for EMA to register such a product will be explicit confirmation of the mechanisms of interactions between nanorobots and proteins\/cells\/tissues\/organs and the proper and broad nanomaterials characterization with particular attention on biosafety and clear <\/span><em><span data-preserver-spaces=\"true\">in vivo<\/span><\/em><span data-preserver-spaces=\"true\"> metabolic behaviour.<\/span><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"1200\" src=\"https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2025\/02\/grafika_post_LN4-1.jpg\" alt=\"\" class=\"wp-image-14127\" style=\"width:327px;height:auto\" srcset=\"https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2025\/02\/grafika_post_LN4-1.jpg 1200w, https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2025\/02\/grafika_post_LN4-1-300x300.jpg 300w, https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2025\/02\/grafika_post_LN4-1-1024x1024.jpg 1024w, https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2025\/02\/grafika_post_LN4-1-150x150.jpg 150w, https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2025\/02\/grafika_post_LN4-1-768x768.jpg 768w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><\/figure>\n<\/div><\/div>\n<\/div>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Challenges and future potential of nanoparticles in medicine<\/h2>\n\n\n<p style=\"text-align: justify;\"><strong><span data-preserver-spaces=\"true\">Nano-based technology<\/span><\/strong><span data-preserver-spaces=\"true\"> has made enormous progress over the last decades. Currently, there are huge numbers of products, not only medicines, that either contain or require nanoparticles for their manufacturing and functionality.<\/span><\/p>\n<p style=\"text-align: justify;\"><strong><span data-preserver-spaces=\"true\">Nanotechnology<\/span><\/strong><span data-preserver-spaces=\"true\"> offers many advantages in various fields of science and life. Many drug products on the market have proven the potential of nanoparticles in many medical applications. Nanoparticles overcome some challenges associated with conventional therapy. However, some issues like side effects and toxicity are still discussed and unsolved. Despite their undoubted limitations, a high level of understanding, an advanced level of development, and a huge range of different biological interaction testing will definitely achieve many strategies for treating, preventing, and diagnosing many diseases, particularly those still untreatable.<\/span><\/p>\n<p style=\"text-align: justify;\"><strong>SciencePharma experts offer support in designing development studies, pre-clinical and clinical trials, as well as preparing complete dossiers. We assist in innovative projects that have the potential to shape the future of medicine.<\/strong><\/p>\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity is-style-dots\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">References<\/h3>\n\n\n<\/p>\n<ol>\n<li><a href=\"https:\/\/efsa.onlinelibrary.wiley.com\/doi\/epdf\/10.2903\/sp.efsa.2024.EN-8826\"><em>https:\/\/efsa.onlinelibrary.wiley.com\/doi\/epdf\/10.2903\/sp.efsa.2024.EN-8826<\/em><\/a><\/li>\n<li><em><a href=\"https:\/\/product.statnano.com\/industry\/medicine\">https:\/\/product.statnano.com\/industry\/medicine<\/a><\/em><\/li>\n<li><em>Abid Haleem, Mohd Javaid, Ravi Pratap Singh, Shanay Rab, Rajiv Suman, Applications of nanotechnology in medical field: a brief review, Global Health Journal,7, 2,2023, <a href=\"https:\/\/doi.org\/10.1016\/j.glohj.2023.02.008\">https:\/\/doi.org\/10.1016\/j.glohj.2023.02.008<\/a>. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2414644723000337\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2414644723000337<\/a><\/em><\/li>\n<li><a href=\"_wp_link_placeholder\" data-wplink-edit=\"true\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8777701\/<\/a><\/li>\n<li><em><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1773224722004646\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1773224722004646<\/a>,<\/em><\/li>\n<li><em><a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/nr\/d4nr00019f\">https:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/nr\/d4nr00019f<\/a><\/em><\/li>\n<li><em>Vivek Verma, Kevin M. Ryan, Luis Padrela, Production and isolation of pharmaceutical drug nanoparticles, International Journal of Pharmaceutics,603,2021,https:\/\/doi.org\/10.1016\/j.ijpharm.2021.120708. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378517321005135\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378517321005135<\/a><\/em><\/li>\n<li><em><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2590049822000777\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2590049822000777<\/a><\/em><\/li>\n<li><em>Kong, X., Gao, P., Wang, J. et al. Advances of medical nanorobots for future cancer treatments. J Hematol Oncol 16, 74 (2023). <a href=\"https:\/\/doi.org\/10.1186\/s13045-023-01463-z\">https:\/\/doi.org\/10.1186\/s13045-023-01463-z<\/a><\/em><\/li>\n<\/ol>\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Have any of you used them? Had a contact with them? Nanoparticles are everywhere around us. Undetectable by the human eye, nanoparticles can exhibit significantly different physical and chemical properties to their larger counterparts. Researchers realized the importance of nanoparticles when they found that size can significantly influence the physiochemical properties of such substances.\u00a0 Although, [&hellip;]<\/p>\n","protected":false},"featured_media":14047,"template":"","meta":{"inline_featured_image":false},"class_list":["post-14072","blog","type-blog","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Nanotechnology is an active area of research and registration<\/title>\n<meta name=\"description\" content=\"Explore the role of nanoparticles in drug delivery, treatment, and regenerative therapies, and their potential to revolutionize medicine.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sciencepharma.com\/pl\/blog\/nanoparticles-nanotechnology-medicine\/\" \/>\n<meta property=\"og:locale\" content=\"pl_PL\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nanotechnology is an active area of research and registration\" \/>\n<meta property=\"og:description\" content=\"Explore the role of nanoparticles in drug delivery, treatment, and regenerative therapies, and their potential to revolutionize medicine.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.sciencepharma.com\/pl\/blog\/nanoparticles-nanotechnology-medicine\/\" \/>\n<meta property=\"og:site_name\" content=\"SciencePharma\" \/>\n<meta property=\"article:modified_time\" content=\"2025-03-13T21:31:38+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2025\/02\/nanoparticles_baner-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"796\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@science_pharma\" \/>\n<meta name=\"twitter:label1\" content=\"Szacowany czas czytania\" \/>\n\t<meta name=\"twitter:data1\" content=\"9 minut\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.sciencepharma.com\/pl\/blog\/nanoparticles-nanotechnology-medicine\/\",\"url\":\"https:\/\/www.sciencepharma.com\/pl\/blog\/nanoparticles-nanotechnology-medicine\/\",\"name\":\"Nanotechnology is an active area of research and registration\",\"isPartOf\":{\"@id\":\"https:\/\/www.sciencepharma.com\/pl\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.sciencepharma.com\/pl\/blog\/nanoparticles-nanotechnology-medicine\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.sciencepharma.com\/pl\/blog\/nanoparticles-nanotechnology-medicine\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2025\/02\/nanoparticles_baner-scaled.jpg\",\"datePublished\":\"2025-02-18T13:16:47+00:00\",\"dateModified\":\"2025-03-13T21:31:38+00:00\",\"description\":\"Explore the role of nanoparticles in drug delivery, treatment, and regenerative therapies, and their potential to revolutionize medicine.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.sciencepharma.com\/pl\/blog\/nanoparticles-nanotechnology-medicine\/#breadcrumb\"},\"inLanguage\":\"pl-PL\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.sciencepharma.com\/pl\/blog\/nanoparticles-nanotechnology-medicine\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"pl-PL\",\"@id\":\"https:\/\/www.sciencepharma.com\/pl\/blog\/nanoparticles-nanotechnology-medicine\/#primaryimage\",\"url\":\"https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2025\/02\/nanoparticles_baner-scaled.jpg\",\"contentUrl\":\"https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2025\/02\/nanoparticles_baner-scaled.jpg\",\"width\":2560,\"height\":796,\"caption\":\"Illustration of a nanoparticle with a size scale showing it ranges from 1 to 100 nanometers. The image emphasizes the tiny scale of nanoparticles, highlighting their potential use in drug delivery, regenerative medicine, and medical therapies.\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.sciencepharma.com\/pl\/blog\/nanoparticles-nanotechnology-medicine\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.sciencepharma.com\/pl\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Blog\",\"item\":\"https:\/\/www.sciencepharma.com\/pl\/blog\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Exploring the potential of Nanoparticles and Nanotechnology systems in medicinal products development and registration\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.sciencepharma.com\/pl\/#website\",\"url\":\"https:\/\/www.sciencepharma.com\/pl\/\",\"name\":\"SciencePharma\",\"description\":\" - More Than Consulting\",\"publisher\":{\"@id\":\"https:\/\/www.sciencepharma.com\/pl\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.sciencepharma.com\/pl\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"pl-PL\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.sciencepharma.com\/pl\/#organization\",\"name\":\"SciencePharma\",\"url\":\"https:\/\/www.sciencepharma.com\/pl\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"pl-PL\",\"@id\":\"https:\/\/www.sciencepharma.com\/pl\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2023\/04\/Science-Pharma_poziom.svg\",\"contentUrl\":\"https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2023\/04\/Science-Pharma_poziom.svg\",\"width\":244,\"height\":40,\"caption\":\"SciencePharma\"},\"image\":{\"@id\":\"https:\/\/www.sciencepharma.com\/pl\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/x.com\/science_pharma\",\"https:\/\/www.linkedin.com\/company\/sciencepharma\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Nanotechnology is an active area of research and registration","description":"Explore the role of nanoparticles in drug delivery, treatment, and regenerative therapies, and their potential to revolutionize medicine.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.sciencepharma.com\/pl\/blog\/nanoparticles-nanotechnology-medicine\/","og_locale":"pl_PL","og_type":"article","og_title":"Nanotechnology is an active area of research and registration","og_description":"Explore the role of nanoparticles in drug delivery, treatment, and regenerative therapies, and their potential to revolutionize medicine.","og_url":"https:\/\/www.sciencepharma.com\/pl\/blog\/nanoparticles-nanotechnology-medicine\/","og_site_name":"SciencePharma","article_modified_time":"2025-03-13T21:31:38+00:00","og_image":[{"width":2560,"height":796,"url":"https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2025\/02\/nanoparticles_baner-scaled.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_site":"@science_pharma","twitter_misc":{"Szacowany czas czytania":"9 minut"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.sciencepharma.com\/pl\/blog\/nanoparticles-nanotechnology-medicine\/","url":"https:\/\/www.sciencepharma.com\/pl\/blog\/nanoparticles-nanotechnology-medicine\/","name":"Nanotechnology is an active area of research and registration","isPartOf":{"@id":"https:\/\/www.sciencepharma.com\/pl\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.sciencepharma.com\/pl\/blog\/nanoparticles-nanotechnology-medicine\/#primaryimage"},"image":{"@id":"https:\/\/www.sciencepharma.com\/pl\/blog\/nanoparticles-nanotechnology-medicine\/#primaryimage"},"thumbnailUrl":"https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2025\/02\/nanoparticles_baner-scaled.jpg","datePublished":"2025-02-18T13:16:47+00:00","dateModified":"2025-03-13T21:31:38+00:00","description":"Explore the role of nanoparticles in drug delivery, treatment, and regenerative therapies, and their potential to revolutionize medicine.","breadcrumb":{"@id":"https:\/\/www.sciencepharma.com\/pl\/blog\/nanoparticles-nanotechnology-medicine\/#breadcrumb"},"inLanguage":"pl-PL","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.sciencepharma.com\/pl\/blog\/nanoparticles-nanotechnology-medicine\/"]}]},{"@type":"ImageObject","inLanguage":"pl-PL","@id":"https:\/\/www.sciencepharma.com\/pl\/blog\/nanoparticles-nanotechnology-medicine\/#primaryimage","url":"https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2025\/02\/nanoparticles_baner-scaled.jpg","contentUrl":"https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2025\/02\/nanoparticles_baner-scaled.jpg","width":2560,"height":796,"caption":"Illustration of a nanoparticle with a size scale showing it ranges from 1 to 100 nanometers. The image emphasizes the tiny scale of nanoparticles, highlighting their potential use in drug delivery, regenerative medicine, and medical therapies."},{"@type":"BreadcrumbList","@id":"https:\/\/www.sciencepharma.com\/pl\/blog\/nanoparticles-nanotechnology-medicine\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.sciencepharma.com\/pl\/"},{"@type":"ListItem","position":2,"name":"Blog","item":"https:\/\/www.sciencepharma.com\/pl\/blog\/"},{"@type":"ListItem","position":3,"name":"Exploring the potential of Nanoparticles and Nanotechnology systems in medicinal products development and registration"}]},{"@type":"WebSite","@id":"https:\/\/www.sciencepharma.com\/pl\/#website","url":"https:\/\/www.sciencepharma.com\/pl\/","name":"SciencePharma","description":" - More Than Consulting","publisher":{"@id":"https:\/\/www.sciencepharma.com\/pl\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.sciencepharma.com\/pl\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"pl-PL"},{"@type":"Organization","@id":"https:\/\/www.sciencepharma.com\/pl\/#organization","name":"SciencePharma","url":"https:\/\/www.sciencepharma.com\/pl\/","logo":{"@type":"ImageObject","inLanguage":"pl-PL","@id":"https:\/\/www.sciencepharma.com\/pl\/#\/schema\/logo\/image\/","url":"https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2023\/04\/Science-Pharma_poziom.svg","contentUrl":"https:\/\/www.sciencepharma.com\/wp-content\/uploads\/2023\/04\/Science-Pharma_poziom.svg","width":244,"height":40,"caption":"SciencePharma"},"image":{"@id":"https:\/\/www.sciencepharma.com\/pl\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/x.com\/science_pharma","https:\/\/www.linkedin.com\/company\/sciencepharma\/"]}]}},"_links":{"self":[{"href":"https:\/\/www.sciencepharma.com\/pl\/wp-json\/wp\/v2\/blog\/14072","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sciencepharma.com\/pl\/wp-json\/wp\/v2\/blog"}],"about":[{"href":"https:\/\/www.sciencepharma.com\/pl\/wp-json\/wp\/v2\/types\/blog"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.sciencepharma.com\/pl\/wp-json\/wp\/v2\/media\/14047"}],"wp:attachment":[{"href":"https:\/\/www.sciencepharma.com\/pl\/wp-json\/wp\/v2\/media?parent=14072"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}